In Vitro Effects of Rabeprazole on Human Pylorus Tone
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منابع مشابه
In Vitro Effects of Rabeprazole on Human Pylorus Tone
BACKGROUND/AIMS It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle. METHODS Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and re-sponse to rabeprazole were recorde...
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Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines
Intracellular proton extrusion in gastric cancer cells has been reported to promote cancer cell survival under acidic conditions via hydrogen/potassium adenosine triphosphatase (H+/K+-ATPase). Rabeprazole is a frequently used second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Therefore, we hypothesized that rabeprazole could reduce the viability of...
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ژورنال
عنوان ژورنال: Journal of Neurogastroenterology and Motility
سال: 2015
ISSN: 2093-0879,2093-0887
DOI: 10.5056/jnm14126